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| Caption | Generation of the Trpm7tm1.1Mkma allele. (A) Schematic diagram of the endogenous Trpm7 locus and the targeting vector used to engineer embryonic stem (ES) cells by homologous recombination. This vector contains a point mutation in exon 33 that changes lysine residue at position 1646 to arginine (K1646R). Restriction enzyme sites are indicated (B, BamHI; Bg, BglII; Sc, ScaI). The length of the genomic fragment is also shown when digested by the indicated enzymes. Probes 5' and 3' were used to screen ES cells for homologous recombination by Southern blotting. DT-A, diphtheria toxin-A; neo, neomycin-resistant gene. | ||||
| Copyright | This image is from Kaitsuka T, Sci Rep 2014;4():5718, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:221252 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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