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| Caption | Insertion site of the Qtrt1Gt(S12-11A1)Sor gene-trap. Gene-trap disruption of Qtrt1 results in loss of Q-tRNA. a, disruption of the Qtrt1 gene by the ROSAFARY gene-trap. The insertion site was mapped by DNA sequencing. Exons are shown numbered in black boxes and introns are depicted as intervening lines. The positions of restriction sites for the SspI DNA endonuclease and probes for Southern blotting are shown. The ROSARARY vector contains 5'- and 3'-long term repeats (L), a splice acceptor site (A), coding sequence for the beta-galactosidase-neomycin fusion protein (betaG), a polyadenylation signal sequence (P), a selectable marker for hygromycin resistance (H), expressed under the PGK promoter (PG), a splice donor site (D), and two frt elements (F). The spliced transcripts from the allele and the encoded fusion protein products are shown. | ||||
| Copyright | This image is from Rakovich T, J Biol Chem 2011 Jun 3;286(22):19354-63 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:173496 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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