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| Caption | Generation of the Eef1a1tm1(Kras*)Arge allele. Homologous recombination in ES cells (knock-in; indicated by X symbols) using a targeting vector that was constructed by inserting an oncogenic Kras cDNA (Kras*; 1.1 kb) into the MCS of the Eef1a1 cassette. A simplified restriction map and the noncoding and coding exons of the locus (open and filled rectangles, respectively) are indicated. Excision of the floxed block from the targeted allele by Cre-mediated recombination allows Kras* transcription driven by the Eef1a promoter. | ||||
| Copyright | This image is from Klinakis A, Proc Natl Acad Sci U S A 2009 Feb 17;106(7):2359-64. Copyright 2009 National Academy of Sciences, U.S.A. J:146290 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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