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| Caption | Generation of the Oprm1tm1Yxp allele. (A) Schematic of the targeting strategy. The exon 11 coding region and its adjacent intron region are replaced with the IRES/Tau/LacZ/loxP-pgk/neo-loxP cassette in 129/Sv ES cells through homologous recombination with the targeting vector. Exon 11 is indicated by a black box: i, the internal ribosome entry sequence (IRES); tk, the herpes simplex virus thymidine kinase gene; neo, the neomycin resistance gene. The expected EcoRV-digested fragment lengths for wild-type and targeted alleles are indicated by arrows. 3' probe is indicated by a short line. Restriction sites: E, EcoRV; R, EcoRI; B, BamHI; X, XbaI. LoxP sites are indicated by triangles. | ||||
| Copyright | This image is from Pan YX, Proc Natl Acad Sci U S A 2009 Mar 24;106(12):4917-22. Copyright 2009 National Academy of Sciences, U.S.A. J:147079 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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