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| Caption | Generation of the Cdkn1ctm1.1(Cdkn1b*)Kei allele. (B) Schematic representations of the wild-type mouse Cdkn1c allele (p57WT), the targeting vector, the knocked-in Cdkn1b allele with a LoxP-neo cassette (p57p27KI-neo), and the knocked-in allele after removal of the neo cassette by Cre recombinase, Cdkn1ctm1.1(Cdkn1b*)Kei (p57p27KI). The expected sizes of DNA fragments that hybridize with the indicated probe in Southern blot analysis are shown. The ORF for mouse Cdkn1b tagged at its NH2 terminus with HA is indicated by the red box. All introns of the Cdkn1c gene were removed in the resulting targeted allele to avoid splicing defects. E1, EcoRI; N, NotI; Nd, NdeI. Indicated are the initiation (1 asterisk) and stop (2 asterisks) codons of the Cdkn1c gene. | ||||
| Copyright | This image is from Susaki E, Proc Natl Acad Sci U S A 2009 Mar 31;106(13):5192-7. Copyright 2009 National Academy of Sciences, U.S.A. J:147145 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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