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| Caption | Generation of the Bdnftm1Bail allele. Strategy to generate promoter IV-specific knockin mice (BDNF-KIV). The targeting construct contained sequences corresponding to Bdnf promoter, exon IV, GFP, and a neomycin cassette (Neo) driven by a PGK promoter in the antisense orientation. The recombinant genome generates an mRNA that translates GFP in lieu of BDNF protein. EcoRV cleavage sites, the positions of the 5' and 3' probes for Southern blot analysis, and locations of genotyping primers as well as splicing donor sites (SD) and splicing acceptor sites (SA) are shown. | ||||
| Copyright | This image is from Sakata K, Proc Natl Acad Sci U S A 2009 Apr 7;106(14):5942-7. Copyright 2009 National Academy of Sciences, U.S.A. J:147571 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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