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| Caption | Generation of the Il2tm1.1Flv allele. The construct for IL-2 knockin mice (NOD.IL-2B6ex1). The DNA for the region surrounding IL-2 Exon I was cloned from a genomic library of the NOD mouse. The IL-2 gene of B6 mice (shaded box) was cloned by PCR and replaced the corresponding NOD sequence. The construct was completed by cloning the long- and short-arm fragments into a pEasyflox plasmid containing a neomycin resistance gene and thymidine kinase gene. (Top) Genome of NOD mice. (Middle) Targeting vector. (Bottom) Genome after successful homologous recombination and removal of the neomycin resistance gene. | ||||
| Copyright | This image is from Kamanaka M, Proc Natl Acad Sci U S A 2009 Jul 7;106(27):11236-40. Copyright 2009 National Academy of Sciences, U.S.A. J:150823 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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