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| Caption | Generation of the Ighmtm1.1(IGH-2)Cog allele. (A) (Top) Structure of the targeted locus (not to scale) showing an unrearranged IgH locus and the extent of the deletion within the Imu-Cmu intron. (Middle) Structure of the targeting vector in which Calpha1 and a neor cassette flanked by loxP sites were inserted in place of Smu. (Bottom) The alpha1KI locus is able to undergo V(D)Jrearrangement after insertion of Calpha1, whereas the neo gene can be deleted by cre-mediated recombination. | ||||
| Copyright | This image is from Duchez S, Proc Natl Acad Sci U S A 2010 Feb 16;107(7):3064-9. Copyright 2010 National Academy of Sciences, U.S.A. J:157575 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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