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| Caption | Generation of the Muc1tm1(cre/ERT2)Lcm allele. Structure of Muc1 locus, targeting vector and targeted allele. The targeting vector was designed to introduce an IRES-CreERT2 cassette downstream of the Muc1 stop codon, along with a FRT-flanked neoR construct for positive G418 selection and a tk gene at the end of each homology arm for negative FIAU selection in ES cells. Dotted lines indicate the boundaries of the 5' and 3' homology arms used for targeting, and the probe used for Southern blotting (outside the 5' homology arm) is indicated in red. Correct targeting introduces a new XbaI site, shifting the predicted restriction fragments detected by this probe. | ||||
| Copyright | This image is from Kopinke D, BMC Dev Biol 2010;10():38, an open-access article, licensee BioMed Central Ltd. J:159445 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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