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| Caption | Generation of the Cd300lbtm1Toki allele. (A) Schematic representation of the wild-type allele, targeted allele, and targeting vector. Black boxes indicate exons. PrDT-A is the diphtheria toxin A fragment gene directed by the MC1 promoter for the negative selection of homologous recombinants, and the zig-zag line indicates the vector-derived sequences. PrNeo3end is the neomycin-resistant gene directed by the PGK gene promoter; it was flanked by frt sequences and conjugated to the lacZ gene with the rabbit Beta-globin polyadenylation signal. These are further flanked by mutant lox71 and WT loxP sequences at the 5' and 3' ends, respectively, and combined to the PGK polyadenylation signal (http://www.cdb.riken.jp/arg/cassette.html). | ||||
| Copyright | This image is from Yamanishi Y, J Exp Med 2010 Jul 5;207(7):1501-11, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:163402 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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