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Molecular Image Detail
Image
Caption Generation of the Ppp1r1btm5.1Pggd allele. (A) Schematic of the generation of the conditional Ppp1r1b (DARPP-32) allele. Blue boxes represent exons; red triangles represent loxP sites. (1) Targeting construct; (2) endogenous Ppp1r1b gene; (3) targeted Ppp1r1b gene; (4) targeted Ppp1r1b gene after in vitro removal of neomycin (NEO) cassette (Ppp1r1btm5.1Pggd), with arrows showing the location of the genotyping primers; (5) Ppp1r1b allele after Cre-mediated deletion of exons 1-4.
Copyright This image is from Bateup HS, Proc Natl Acad Sci U S A 2010 Aug 17;107(33):14845-50. Copyright 2010 National Academy of Sciences, U.S.A. J:163700
Associated
Alleles
Symbol Name
Ppp1r1btm5.1Pggd protein phosphatase 1, regulatory inhibitor subunit 1B; targeted mutation 5.1, Paul Greengard
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
MGI 6.13 		The Jackson Laboratory