| Image |
|
||||
| Caption | Generation of the Mkxtm1Miu allele. (a) Schematic representation of the Mkx genomic locus, gene targeting construct, and the targeted allele. The top line shows the wild-type 5' Mkx locus with exons 1-5 denoted as E1-E5. The middle line shows the Mkx targeting construct designed for the replacement of exon 3 with the neo cassette. The 5' and 3' homologous regions of the targeting construct were 1.9 and 12.1 kb, respectively. On the bottom line, the mutant allele is illustrated. TK, thymidine kinase; Ba, BamHI; Bg, BglII; Xb, XbaI; closed boxes, untranslated sequences; open boxes, coding sequences; red boxes, homeodomain-coding sequences. Only relevant restriction enzyme sites are shown. The probe used for the Southern blot analysis and the primers used for PCR are indicated by the bar and arrowheads, respectively. | ||||
| Copyright | This image is from Kimura W, Genesis 2011 Jan;49(1):2-9, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:167977 | ||||
|
Associated Alleles |
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 11/12/2024 MGI 6.24 |
|
|
|
||
Analysis Tools