Phenotype Image Detail

Image

Caption

Panels A-C: Coronal sections through the head showing intact hard palate of E18.5 embryos of wildtype mice (A), cleft palates Fgfr2^tm1Schl/Fgfr2^tm1Schl (B) and Fgfr2^tm2Schl/Fgfr2 (C). Panels D-F: Trachea showing cartilaginous rings in wildtype (D) however in the Fgfr2^tm1Schl/Fgfr2^tm1Schl and the Fgfr2^tm2Schl/Fgfr2^tm2Schl mice there is no seperation of the traceal cartilage into rings, and the trachea appears like a smooth cartilaginous tube. Panels G-I: The knee joints of E18.5 embryos of wild type (G) and Fgfr2^tm2Schl/Fgfr2^tm2Schl (I) are similar whereas the joint spaces did not form in the Fgfr2^tm1Schl/Fgfr2tm1Schl (H). Panels J-L: Normal elbow joint development in the wildtype (J) and Fgfr2^tm2Schl/Fgfr2^tm2Schl (L), Fgfr2^tm1Schl/Fgfr2^tm1Schl mice (K) display agenesis of joint spaces. Abbreviations: coronoid process (C); cricoid cartilage (Cr); femur (F); fibula (Fi); humerus (Hu); hard palate (HP); nasal septum (N); olecranon process (O); patella (P); radius (R); tongue (T); tracheal cartilage rings (Tc); tibia (Ti); trochlear notch (Tr); thyroid cartilage rings (Tc); tibia (Ti); trochlear notch (Ty); thyroid cartilage (Ty) and ulna (U). Scalebars 200um.

Associated
Alleles

Symbol	Name
Fgfr2^tm1Schl	fibroblast growth factor receptor 2; targeted mutation 1, Joseph Schlessinger
Fgfr2^tm2Schl	fibroblast growth factor receptor 2; targeted mutation 2, Joseph Schlessinger

Associated
Genotypes

Allelic Composition	Genetic Background
Fgfr2^tm1Schl/Fgfr2^tm1Schl	involves: 129S1/Sv
Fgfr2^tm2Schl/Fgfr2^tm2Schl	involves: 129S1/Sv * BALB/c * C57BL/6

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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