Phenotype Image Detail

Image

Caption

Melanosomes in the Lyst^bg-grey/Lyst^bg-grey mice (B & D) are larger and irregularly shaped compared to the +/+ wild-type (A & C) in hair follicle-associated melanocytes (arrows in A & B) and choroid melanocytes (long arrows in C & D). In comparison with the insert in (A) of the +/+ wild-type mouse, the insert in (B) of the Lyst^bg-grey/Lyst^bg-grey mouse shows secretory granules in dermal mase cells are larger and less numerous. In the neural tube derived pigment epithelium of the retina there are altered melanosomes (arrows in C & D). The electron microscopic image (E) reveals fusion of melanosomes of different maturity (white arrows) in melanocytes of the iris in the Lyst^bg-grey/Lyst^bg-grey. Abbreviations: DP: dermal papilla; PPR: pars pigmentosa retinae. Scalebars: A-D 25um; inserts 4um; E 800 um

This image is from Runkel F, Mamm Genome 2006 Mar;17(3):203-10 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:106442

Associated
Alleles

Symbol	Name
Lyst^bg-grey	lysosomal trafficking regulator; beige grey

Associated
Genotypes

Allelic Composition	Genetic Background
Lyst^bg-grey/Lyst^bg-grey	C57BL/6-Lyst^bg-grey

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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