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| Caption | Compared with the ridged and laminated appearance of the normal stratum corneum of the wild-type control (A), the stratum corneum of the Tgm1tm1Kfyn/Tgm1tm1Kfyn is thickened with prominent granules of flattened keratohyalin (B). In situ hybridzation of TGase 1 mRNA is localized in the upper spinous and granular layers of the wild-type control epidermis of 18.5dpc fetal mouse skin (C), but undetectable in the Tgm1tm1Kfyn/Tgm1tm1Kfyn epidermis (D). Keratin 14 mRNA is evident in a few epidermal layers, including the basal layer in both the Tgm1tm1Kfyn/Tgm1tm1Kfyn and the wild-type control E & F). Arrowheads indicate basement membrane. Abbreviations: stratum corneum (C); stratum granulosum (G); stratum spinosum (S); stratum basale (B). Scalebar: A-F 30um | ||||
| Copyright | This image is from Matsuki M, Proc Natl Acad Sci U S A 1998 Feb 3;95(3):1044-9. Copyright 1998 National Academy of Sciences, U.S.A. J:45653 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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