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| Caption | A: The epidermis of the control and Slc27a4wrfr/Slc27a4wrfr appears similar, although the dermis appears more cellular in the Slc27a4wrfr/Slc27a4wrfr. At E17.5 the Slc27a4wrfr/Slc27a4wrfr epidermis is thicker with a flattened skin surface. At birth (PO) the Slc27a4wrfr/Slc27a4wrfr epidermis is on average three times thicker then the control (Bars indicate length), as well as having fewer and abnormally arranged keratohyalin granules (brackets). B: Staining for keratin 14 (K14) at E17.5 shows an increased thickness and flattening of the Slc27a4wrfr/Slc27a4wrfr. Keratin 6 (K6) is only express in the Slc27a4wrfr/Slc27a4wrfr. Loricrin (Lor) was not concentrated at the plasma membrane of granular cells in the Slc27a4wrfr/Slc27a4wrfr. C: E17.5 embryos incubated overnight show penetration into the Slc27a4wrfr/Slc27a4wrfr but not the control. D: Oil red O staining shows numerous fat droplets in the squamous layer of the Slc27a4wrfr/Slc27a4wrfr but not the control. | ||||
| Copyright | This image is from Moulson CL, Proc Natl Acad Sci U S A 2003 Apr 29;100(9):5274-9. Copyright 2003 National Academy of Sciences, U.S.A. J:83282 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/05/2024 MGI 6.24 |
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