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Phenotype Image Detail
Image
Caption A: Wild-type and Sirt1tm1Fwa/Sirt1tm1Fwa embryos at E16.5. * indicates exencephaly in the homozygous embryo. B: Whole mouse eyes from E16.5 embryos. Arrow indicates open optic tissue in the homozygous mouse eye. C: Retinal sections from 5 week old mice. Rosette-like structure. D: An elargement of (C). E: Retinal sections from E18.5 wild-type and homozygous embryos. F: Sections through E18.5 hearts. * indicates the VSD. G: Section through E18.5 homozygous heart showing elongated atrioventricular valve (arrow> Abbreviations: ganglion cell layer (gl); inner plexiform layer (ipl) inner nuclear layer (inl); outer plexiform layer (opl); outer nuclear layer (onl); inner segment (is); outer segment (os); pigmented epithelium (pe); left ventricle (LV); right ventricle (RV).
Copyright This image is from Cheng HL, Proc Natl Acad Sci U S A 2003 Sep 16;100(19):10794-9. Copyright 2003 National Academy of Sciences, U.S.A. J:85542
Associated
Alleles
Symbol Name
Sirt1tm1Fwa sirtuin 1; targeted mutation 1, Frederick W Alt
Associated
Genotypes
Allelic Composition Genetic Background
Sirt1tm1Fwa/Sirt1tm1Fwa involves: 129/Sv * 129S6/SvEvTac

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory