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| Caption | A & B: Hematoxylin and eosin staining of retinal sections of wild-type (A) and Bbs4tm1Vcs/Bbs4tm1Vcs (B) mice. The entire photoreceptor layer is absent in the homozygous mouse section. C & D: Labeling of rods with anti-Opsin (green) from a wild-type (C) and homozygous mutant mouse (D). The lack of labeling in the homozygous mutant mouse retinal section confirms the absence of the photoreceptors. E & F: Labeling of rods with anti-Opsin (green) from a 6 week old wild-type (E) and Bbs4tm1Vcs/Bbs4tm1Vcs (F) mouse, demonstrating the presence of photoreceptors. The outer nuclear and photoreceptors layers in the homozygous mouse section are approximately one-half the thickness of the wild-type mouse section, indicating significant photoreceptor cell degeneration. Abbreviations: choroids (CH); retinal pigment epithelium (RPE); outer segment (OS); outer nuclear layer (ONL); inner nuclear layer (INL); ganglion cell layer (GCL | ||||
| Copyright | This image is from Mykytyn K, Proc Natl Acad Sci U S A 2004 Jun 8;101(23):8664-9. Copyright 2004 National Academy of Sciences, U.S.A. J:90812 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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