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| Caption | A & B: The Flt4Chy/Flt4+ mice were recognized by the accumulation of chyous fluid into the abdomen (red arrow). Wild-type littermate shown as comparison. The stomach is marked with a dashed line. C-F: The subserosal lymphatic vessels are enlarged in the heterozygous mouse intestine as detected by VEGFR-3 IHC ( C & D), and by VEGFR-3 wholemount staining (E & F). G: The feet of the heterozygous mice are swollen (arrows), when compared with wild-type littermates. H & I: MRI of the mouse feet shows the prominent hyperintensity in the heterozygous mouse foot, which is absent in the wild-type mouse. J & K: The lymphatic endothelium (black arrows) of E15.5 skin was visualized by VEGFR-3 IHC in the heterozygous and wild-type mice. Note the absence of the lymphatic vessels in the heterozygous mice. L & M: PECAM-1 IHC reveals no differences in the blood vasculature (red arrows). N & O: VEGFR-3 IHC indicates that the lymphatics surrounding the aorta (a) in the heterozygous mice are similar to those of the wild-type mice. P & Q: The hematoxylin and eosin staining of the back skin shows that the dermis (d) and s.c. adipose tissue (sc) are thickened in the heterozygous mice when compared to the wild-type littermate. R & S: The transport of the Evans blue dye into the collecting lymphatic vessels (arrows) was visualized in the wild-type but not the heterozygous mice after intradermal injection of the dye. Scalebars: A & B: 5mm; C & D: 90um; E & F: 200um; G: 5mm; H & I: 100um; J-M: 70um; N & O: 200um; P & Q: 210um; R & S: 1.5mm | ||||
| Copyright | This image is from Karkkainen MJ, Proc Natl Acad Sci U S A 2001 Oct 23;98(22):12677-82. Copyright 2001 National Academy of Sciences, U.S.A. J:72387 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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