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Phenotype Image Detail
Image
Caption A: External ear and head morphology of a wild-type (Pact +/+, left) and Prkratm1Gcs/Prkratm1Gcs (Pact -/-, right) mice. Note the extremely reduced size of the pinna as well as the shortened nose and prominent bossing of the forehead of the homzygous mutant mouse as compared to the wild-type mouse. B: Internal ear structure of a wild-type (left) and homozygous mutant (right) mouse. The most abnormal ear structures in the homozygous mouse as seen above the ear canal, tympanic membrane, ossicles, and middle ear space. There is no impairment in the size of the cochlea in the homozygous mouse. Also show in the stapedial artery. Abbreviations: ear canal (ec); tympanic membrane (tm); ossicles (os); middle ear space (mes); cochlea (co); stapedial artery (sa).
Copyright This image is from Rowe TM, Proc Natl Acad Sci U S A 2006 Apr 11;103(15):5823-8. Copyright 2006 National Academy of Sciences, U.S.A. J:108297
Associated
Alleles
Symbol Name
Prkratm1Gcs protein kinase, interferon inducible double stranded RNA dependent activator; targeted mutation 1, Ganes C Sen
Associated
Genotypes
Allelic Composition Genetic Background
Prkratm1Gcs/Prkratm1Gcs either: B6.Cg-Prkratm1Gcs or (involves: C57BL/6)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory