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| Caption | A: Radiograph comparison of 16 week old bones in Ctsktm1Psa/Ctsktm1Psa and control mice. Femur,(left). Humeri (center). Note extensive trabeculation of bone-marrow space (beginning at the distal end) in the homozygous mouse. Lumbar vertebrae (right), (note the very dense and irregular distribution of spongiosa in the homozygous mouse). B & C: SEM images of 3-month-old proximal femura (b, with retained epiphyses) and tibiae (c, with epiphyses removed). Note the retention of cancellous bone in the shafts of the homozgous mutant mouse bones. Field widths: b = 7.69 mm; c = 5.84 mm D & E: Histological sections of the meta- and epiphysis of control (d) and homozygous mouse (e) femura embedded in methyl methacrylate and stained with McNeil's tetrachrome. Note the unresorbed primary spongiosa in e. F & G: Histological sections (sagittal plane) through the ventral half of thoracic vertebrae derived from control (f) and homozygous mice (g). Abbreviations: bone marrow (BM); cortical bone (CB); growth plate (GP) Scalebar: D-G: 400um | ||||
| Copyright | This image is from Saftig P, Proc Natl Acad Sci U S A 1998 Nov 10;95(23):13453-8. Copyright 1998 National Academy of Sciences, U.S.A. J:50934 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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