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| Caption | A-F are images taken from Bouin's solution-fixed, paraffin-embedded, and periodic acid/Schiff reagent-stained testis cross sections. (A) Robust spermatogenesis in an 8-week-old wild-type mouse. (B) A low-power image shows disrupted spermatogenesis in an 8-week-old chimeric male mouse. Numbers of late spermatids are depleted, and multiple vacuoles (arrows) are present in the seminiferous epithelium. C) A tubule from a chimeric male mouse containing spermatocytes (arrows), but no spermatids. Vacuoles (V) are present within the epithelium. (D) A tubule from a chimeric mouse containing fewer round spermatids (arrows) and late spermatids (arrowheads). Vacuoles (V) are present within the epithelium. (E) A stage X tubule from a wild-type male displaying synchronized germ-cell maturation. All spermatids are at step 10 (arrows), which coexist with late pachytene and leptotene spermatocytes. (F) A representative tubule with asynchronized development of haploid cells in a young (4-week-old) chimeric mouse testis. Spermatids at step 5 (circled in red), steps 9-10 (yellow), and steps 11 and 12 (blue) are present simultaneously in one stage. Some spermatids appear to be degenerating (green). G-J are images of TUNEL assay with 4% paraformaldehyde-fixed, paraffin-embedded testis cross sections. (G) Three TUNEL-positive germ cells (arrows) are visible in a cross section of a wild-type testis (8-week-old). H) Numerous TUNEL-positive germ cells (arrows) are present in the chimeric mouse testis (12-week-old). In wild-type testis, TUNEL-positive spermatids are rarely seen. (I) Four TUNEL-positive round spermatids (arrowheads) and one TUNEL-positive spermatogonium (arrow) are present in this cross section of the chimeric mouse testis. (J) Multiple TUNEL-positive spermatids (arrowheads) and spermatocytes (arrows) are present in a cross section of the chimeric testis at 8 weeks of age. Some morphologically apparent degenerating spermatids are TUNEL-negative (circles). Magnifications: A,B, G & H: x200; C,D,E,I & J: x400 | ||||
| Copyright | This image is from Yan W, Proc Natl Acad Sci U S A 2004 May 18;101(20):7793-8. Copyright 2004 National Academy of Sciences, U.S.A. J:89621 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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