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| Caption | A & B: Autofluorescence in the hippocampus of 3-month-old wild-type (A) and Clcn6tm1Tjj/Clcn6tm1Tjj (B) littermates. Note the localization in initial axon segments in the homozygote (arrow). C: Golgi staining of a homozygote cortical neuron reveals proximal axonal swelling (a meganeurite; arrow) that was seen in 20% of cortical neurons; age, 6 months. D: Electron microscopy reveals a similar swelling of a hippocampal axon because of material accumulation (arrow). The neuronal plasma membrane is surrounded by a dashed line; n, nucleus. E: Avacuolar, lipofuscin-like lipopigment that was nearly always associated with lipid droplets in a homozygous cortical neuron. F & G: Electron microscopy of DRG axons (ax) from wild-type (F) and homozygote (G) P90 littermates reveals storage material in the homozygote. Scalebars: A-C: 20um; D: 2um; E: 400um; F & G: 1um | ||||
| Copyright | This image is from Poet M, Proc Natl Acad Sci U S A 2006 Sep 12;103(37):13854-9. Copyright 2006 National Academy of Sciences, U.S.A. J:113752 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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