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Phenotype Image Detail
Image
Caption Histopathological sections from +/+ wild-type ( A & C) and Myh6tm1Jse/Myh6+ (B & D-F) mice stained with hematoxylin and eosin (A and B) and Masson trichrome (C-F). Normal myofibers (A) without fibrosis (C; note absence of blue stained collagen) are found in wild-type mice. Histopathology of Myh6tm1Jse/Myh6+ mice shows severe myocyte disarray (B) and diffuse (D) and focal ( E & F) patterns of fibrosis. Scalebars: A & B: 400um; E & F: 200um; C & D: 100um
Copyright This image is from Wolf CM, Proc Natl Acad Sci U S A 2005 Dec 13;102(50):18123-8. Copyright 2005 National Academy of Sciences, U.S.A. J:104363
Associated
Alleles
Symbol Name
Myh6tm1Jse myosin, heavy polypeptide 6, cardiac muscle, alpha; targeted mutation 1, Jonathan G Seidman
Associated
Genotypes
Allelic Composition Genetic Background
Myh6tm1Jse/Myh6+ 129S.129X1-Myh6tm1Jse
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory