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| Caption | A: Immunohistochemical staining for K14 (dark gray) in a sagittal section from a normal neonatal incisor localizes to the reduced enamel epithelium (re) on the labial surface. B: Eruption of both incisors and molars (enlarged in Insets) is readily apparent in the maxilla and mandible of an adult Pthlhtm1Hmk/Pthlhtm1Hmk mouse expressing Tg(Col2a1-PTHLH)2Ecw and Tg(KRT14-PTHLH)7Wmp. C: A sagittal radiograph of an adult homozygous mouse expressing Tg(Col2a1-PTHLH)2Ecw and Tg(KRT14-PTHLH)7Wmp clearly reveals the malocclusion of the incisors caused by the underlying chondrodystrophy. Note the restoration of root extension in the lower incisor (arrowhead). Scalebar: 27um | ||||||||
| Copyright | This image is from Philbrick WM, Proc Natl Acad Sci U S A 1998 Sep 29;95(20):11846-51. Copyright 1998 National Academy of Sciences, U.S.A. J:50144 | ||||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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