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| Caption | A: Pancreatic sections from wild-type and Cyb5r4tm1Hfb/Cyb5r4tm1Hfb male mice at 4, 7 and 21 weeks of age that are stained in situ using anti-insulin antibody for beta cells and anti-glucagon antibody for alpha cells. The immunostains are shown in brown color. B: Electron micrographs from 7-week-old male wild-type and homozygous mutant mice. (a) In wild type islets, well granulated beta cells are the predominant islet cell type. Alpha cells are less numerous. (b) Dearth of beta cells in a homozygous mutant islet. The beta cell in the field is heavily degranulated. Mitochondria are increased in number and size. Golgi stacks are prominent, but beta granules are reduced in number primarily associated with the plasma membrane (emiocytosis). (c) Electron-dense inclusions (arrows) are present within some mitochondria in an islet from the same homozygous mutant mouse shown in b. Abbreviations: Alpha: (alpha cells); Beta: (beta cells); Mitochondria: (M); Golgi stacks: (G); beta granules: (GR) | ||||
| Copyright | This image is from Xie J, Proc Natl Acad Sci U S A 2004 Jul 20;101(29):10750-5. Copyright 2004 National Academy of Sciences, U.S.A. J:91486 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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