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| Caption | Smad4tm1Cxd/Smad4tm1Cxd embryos (right) and their littermate controls (left). A: E6.5 embryos. Arrow points to the boundary between extraembryonic and embryonic portions of the control embryo. The mutant embryo is round without such a boundary. B: E7.5 embryos. Mutant embryos remain small, however, with a relatively large Reichert's membrane (arrow). C: E8.5 embryos. Arrow points to mutant embryo. Note the increased sizes of mutant embryos compared with those shown at E6.5 and E7.5. D-F: Whole mount hybridization showing the T expression in E7 normal (D), E8.5 mutant(E) and its littermate control (F) embryos. T transcripts were absent in the mutant (E, arrow) but are detected in the control embryos ( D & F, arrows). Lim1 transcripts were also absent in the E8.5 mutant (small arrow in G) but are detected in the control embryos. Abbreviations: ectoplacental cone (epc); head (he); headfold (hf) Scale bar: 270um | ||||
| Copyright | This image is from Yang X, Proc Natl Acad Sci U S A 1998 Mar 31;95(7):3667-72. Copyright 1998 National Academy of Sciences, U.S.A. J:46852 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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