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Phenotype Image Detail
Image
Caption Wild type and Ppp3cbtm1Jmk/Ppp3cbtm1Jmk mice subjected to 14 days of Iso infusion or pressure overload. (Upper) Macroscopic hematoxylin and eosin stained histological sections of hearts demonstrate a noticeable increase in heart size in wild type mice, but not homozygous mutant mice. (Lower) Microscopic analysis of trichrome stained histological sections demonstrate comparable myofibrillar organization and interstitial fibrosis in wild type and homozygous mutant mice treated with Iso or by pressure overload.
Copyright This image is from Bueno OF, Proc Natl Acad Sci U S A 2002 Apr 2;99(7):4586-91. Copyright 2002 National Academy of Sciences, U.S.A. J:75775
Associated
Alleles
Symbol Name
Ppp3cbtm1Jmk protein phosphatase 3, catalytic subunit, beta isoform; targeted mutation 1, Jeffery D Molkentin
Associated
Genotypes
Allelic Composition Genetic Background
Ppp3cbtm1Jmk/Ppp3cbtm1Jmk involves: 129S6/SvEvTac * C57BL/6
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory