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| Caption | Histological appearance of Stk11tm1.1Jish/Stk11+ mice. d-i: Histological examination of polyps at 14 months. (d & f-i) Hematoxylin and eosin staining. (e) Azan staining. (d) Low power section of polyp protruding into gastric lumen. (e) The core of the polyp is formed by a tree-like branching of the muscularis mucosa with connective tissue (arrow). (f) The polyps consist of two types of cells; surface mucous epithelium-like cells (SC) and pyloric gland-like cells (PC) and form glandular tubules like gastric pits (LGP). (g) Surface mucous epithelium like cells of columnar or high columnar type (SC). Pyloric gland like cells have large nuclei and pale cytoplasm (PC). (h) High nuclear density, nuclear atypia, and mitosis (arrowhead) are observed in proportion of proliferating cells. (i) Pyloric gland-like cells also contain eosinophilic material in the cytoplasm. Magnifications: d: x5; e: x20; f: x100; g-i: x200. | ||||
| Copyright | This image is from Jishage K, Proc Natl Acad Sci U S A 2002 Jun 25;99(13):8903-8. Copyright 2002 National Academy of Sciences, U.S.A. J:77213 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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