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| Caption | A: Accumulation of megakaryocytes in the bone marrow and spleen of Gata1Plt13/Gata1+ mice. In comparison with the wild type mouse tissues (left), there are a significant number of megakaryocytes demonstrated hyperchromatic nuclei and a reduced amount of cytoplasm (arrows) in the heterozygote tissues (right). B: Electron micrographs of megakaryocytes from wild-type mice demonstrate the expansive cytoplasm and complex demarcation membrane system that are characteristic of these cells. Heterozygous mouse megakaryocytes have large, multilobed nuclei but generally have reduced cytoplasm with a poorly developed demarcation membrane system. Scale bar: 5um | ||||
| Copyright | This image is from Majewski IJ, Proc Natl Acad Sci U S A 2006 Sep 19;103(38):14146-51. Copyright 2006 National Academy of Sciences, U.S.A. J:113720 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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