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Phenotype Image Detail
Image
Caption H & E staining of skin sections from 16 week old mice demonstrates that Mapk8tm1Flv/Mapk8tm1Flv mice have a thin epidermis, whereas Mapk9tm1Flv/Mapk9tm1Flv mice have a thick epidermis, compared with wild type control mice. Immunohistochemical staining for keratin 6 and 10, loricrin, PCNA and p63 indicates abnormal expression in mutant mice. Markedly reduced expression of EGF mRNA in the skin of mutant mice, compared with wild type control, was detected by in situ hybridization.
Copyright This image is from Weston CR, Proc Natl Acad Sci U S A 2004 Oct 28;101(39):14114-9. Copyright 2004 National Academy of Sciences, U.S.A. J:93433
Associated
Alleles
Symbol Name
Mapk8tm1Flv mitogen-activated protein kinase 8; targeted mutation 1, Richard Flavell
Mapk9tm1Flv mitogen-activated protein kinase 9; targeted mutation 1, Richard Flavell
Associated
Genotypes
Allelic Composition Genetic Background
Mapk8tm1Flv/Mapk8tm1Flv B6.129S1-Mapk8tm1Flv
Mapk9tm1Flv/Mapk9tm1Flv B6.129S2-Mapk9tm1Flv
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/05/2024
MGI 6.24 		The Jackson Laboratory