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| Caption | A: Gross morphology of a wild type and Mapk14tm1Mms/Mapk14tm1Mms littermate at 11.0dpc, showing developmental retardation of the mutant. B & C: Ventral view of the placentas of a wild type and mutant mouse, showing apparent decreased vascularization of the mutant mouse placenta, as shown by its paler color (arrow in C). D-K: Hematoxylin and eosin stained sections of placentas from wild type (D,F,H & J) and homozygous mutant littermates (E,G,I & K). D & E: At 10.5dpc, the developing labyrinth and spongiotroplast layers found in the wild type (D) are significantly decreased in thickness in the mutant (E, arrow). F & G: High power views show a nearly complete lack of circulating fetal blood cells in the mutant. H & I: By 11.5dpc, that labyrinth layer is essentially missing and the spongiotrophoblast layer is greatly diminished in the mutant compared with the wild type mouse. J & K: High power views show that the placental vasculature with differentiated endothelial cells and circulating fetal blood cells (J) is nearly completely abolished in the mutant mouse, which instead contains apparent necrotic regions (K,arrows). (Scale bars in A-C represent 0.5mm; bars in D-K represent 100um). Abbreviations: al, allantois; ch, chorionic plate; en, endothelial cells; fb, fetal blood cells; gi, trophoblast giant cells; la, labyrinthine trophoblast; ma, maternal decidual tissue; sp, spongiotrophoblast. | ||||
| Copyright | This image is from Mudgett JS, Proc Natl Acad Sci U S A 2000 Sep 12;97(19):10454-9. Copyright 2000 National Academy of Sciences, U.S.A. J:73417 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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