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| Caption | A: Formation of osteosarcomas in Wwoxtm1Ria/Wwoxtm1Ria mice. Typical histological appearance is shown for one tumor (A1-A3, toluidine blue with von Kossa stain). Calcified chondroid tissue forms the diaphysis (A1, arrowhead) with immature trabeculae in the osteosarcoma (A2). A section of diaphysis of a wild type mouse from the same litter showing a single layer of osteoblasts constituting the endosteal and periosteal surfaces of cortical bone (A3). Decalcified femur bone, age 17 days (A4), reveals a cartilage cap under the periosteum with enlarged hypertrophic cells forming a growth plate (Aa). Proliferating cells adjacent to this lesion appear to be transformed (Ab). Hyperproliferative periosteal cells along the diaphysis (Ac). | ||||
| Copyright | This image is from Aqeilan RI, Proc Natl Acad Sci U S A 2007 Mar 6;104(10):3949-54. Copyright 2007 National Academy of Sciences, U.S.A. J:120064 | ||||
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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