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Phenotype Image Detail
Image
Caption A: Large vascular lesion (arrow) visible on the surface of the brain of a 13 month old Ccm2Gt(RRG051)Byg/Ccm2+ mouse. B: Sectioning of the lesion reveals a mass of closely packed, tortuous blood vessels. C: Hemorrhaging visible of the surface of the brain of a 37 day old heterozygous mouse. D-F: Vascular malformations consisting of clusters of dilated blood vessels in the brain of a 37 day old mouse. G: Diffuse hemorrhage in the brain of the 37 day old mouse. H: Hemosiderin deposits (blue stain) present in the brain of the 37 day old mouse are indicative of chronic hemorrhaging. (B, D-G) Hematoxylin and eosin staining; (H) Prussian blue stain with nuclear fast red counterstain.
Copyright This image is from Plummer NW, Mamm Genome 2006 Feb;17(2):119-28 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:105314
Associated
Alleles
Symbol Name
Ccm2Gt(RRG051)Byg cerebral cavernous malformation 2; gene trap RRG051, BayGenomics
Associated
Genotypes
Allelic Composition Genetic Background
Ccm2Gt(RRG051)Byg/Ccm2+ involves: 129P2/OlaHsd * C57BL/6J

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory