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| Caption | Morphology of aortic lesions from proxmila aortic roots. Representative section from the aortic root (at the level of the first coronary) showing lesions in a Apoetm1Unc/Apoetm1Unc mouse at low (x4) (A) and high magnification detail of lower right profile in A (X20). B: Representative section at the aortic root lesion from a Apoetm1Unc/Apoetm1Unc Ttpatm1Far/Ttpatm1Far mouse at low (x4) (C) and high magnification detail of lower right profile in C (x20). D: Lesions in double homozygous mutant mice show more complex features, including a large necrotic core (NC), numerous needle shaped lucencies indicative of cholesterol crystals (C), and fibrous capping (FC) from smooth muscle cells (stained red). Within the lesion core, greenish blue staining represents proteoglycan, and yellow staining represents collagen. | ||||||
| Copyright | This image is from Terasawa Y, Proc Natl Acad Sci U S A 2000 Dec 5;97(25):13830-4. Copyright 2000 National Academy of Sciences, U.S.A. J:66419 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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