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| Caption | A-E: P12 normal mouse skin. F-J: P12 Apctm2Rak/Apctm2Rak Tg(KRT14-cre)8Brn/0 mutant mouse skin. K-N: P12 normal oral cavity. O-R: P12 mutant oral cavity. Stained with hematoxylin and eosin for histology (A,F,K-L,O-P), Ki67 (B,G), B-catenin (C,H,M,Q), K14 (D,I,N,R) and K6 (E,J). Aberrant follicular morphogenesis, characterized by formation of irregularly spaced, nonpolarized hair follicles, in mutant skin is evident. Despite the abnormal histology, proliferation seems to be confined to the hair bulb-like structures (arrow in [G], inset [G' ] at higher magnification), but in mutant skin (arrows in [H], inset [H' ] at higher magnification) and oral cavity (arrows in insets [Q' ] at higher magnification) elevated cytosolic localization of B-catenin is detected in some cells. Scale bars: A-F, H-J 50um; K & O: 250um; G, L-N. P-R: 100um; Q': 20um | ||||||
| Copyright | This image is from Kuraguchi M, PLoS Genet 2006;2(9):e146, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:114152 | ||||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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