Phenotype Image Detail

Image

Caption

(B-D) Sections of testis from 14 day old (B), 21 day old (C), and 42 day old mice (D) stained with hematoxylin and eosin. Wild type mouse left colummn, Dmrtc2^tm1.2Zark/Dmrtc2^tm1.2Zark right column. No significant difference is observed at 14 days (B), but by 21 days some tubules are lacking abundant spermatocytes (C, asterisk) or cells with typical apoptotic morphology are present (open arrowhead, C and D). Mutant mouse tubules contain multinucleate cells (closed arrowhead, D). (E & F) Testes from wild type and homozygous mutant littermates were analyzed by TUNEL labeling to detect apoptotic cells. Testis sections from 21 day old (E) and 6 week old mice (F). Apoptotic cells (brown) are much more abundant in seminferous tubules of homozygous mutant mice relative to wild type. Scale Bars: B-F: 100um

This image is from Kim S, PLoS Genet 2007 Apr 20;3(4):e62, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:121537

Associated
Alleles

Symbol	Name
Dmrtc2^tm1.2Zark	doublesex and mab-3 related transcription factor like family C2; targeted mutation 1.2, David Zarkower

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