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| Caption | Hematoxylin/eosin stained 6 month old wild type (A) and Bbs1tm1Vcs/Bbs1tm1Vcs (B) seminiferous tubules show a lack of spermatozoa flagella. Hematoxylin and eosin stained 6 month old wild type (C) and mutant (D) retinas show a loss of the outer nuclear layer in the mutant retinas and degeneration of photoreceptor inner and outer segments. TEM analysis of a 5 month old mutant retina (E) shows disrupted morphology and disorientation of photoreceptor OS membranous discs. Connecting cilia are visible in sagittal sections (arrow). Connecting cilia were observed en face between the IS and the OS (F). Abbreviations: CH; choroid; RPE, retinal pigment epithelium; OS, outer segments; IS, inner segments; ONL, outer nuclear layer; INL, inner nuclear layer; GCL, ganglion cell layer; PC photoreceptor cells. Scale bars: A-D, 50um; E, 500nm; F, 200nm | ||||
| Copyright | This image is from Davis RE, Proc Natl Acad Sci U S A 2007 Dec 4;104(49):19422-7. Copyright 2007 National Academy of Sciences, U.S.A. J:128532 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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