Phenotype Image Detail

Image

Caption

Hematoxylin and eosin stained testis sections showing a normal appearance and organization in the Kit^Mhdasco1/Kit^Mhdasco1, Kit^Whc1/Kit^Whc1 and Kit^Mhdasco5/Kit^Mhdasco5 mutants. On the contrary, the seminferous tubules of the Kit^Mhdasow3/Kit^Mhdasow3 adult mutant mouse are lacunar with a complete absence of all the layers coresponding to the differentiation of spermatogonial stem cells. The beta-galactosidase pattern of expression reveals that Kit^tm1Alf/Kit^Mhdasow3 mutant mice showed no pattern of spermatogenesis compared to Kit^tm1Alf/⁺.

This image is from Magnol L, BMC Dev Biol 2007;7():81, an open-access article, licensee BioMed Central Ltd. J:125831

Associated
Alleles

Symbol	Name
Kit^Mhdasco1	KIT proto-oncogene receptor tyrosine kinase; Martin Hrabe de Angelis spotted coat 1
Kit^Mhdasco5	KIT proto-oncogene receptor tyrosine kinase; Martin Hrabe de Angelis spotted coat 5
Kit^Mhdasow3	KIT proto-oncogene receptor tyrosine kinase; Martin Hrabe de Angelis sister of W 3
Kit^tm1Alf	KIT proto-oncogene receptor tyrosine kinase; targeted mutation 1, Jean-Jacques Panthier
Kit^Whc1	KIT proto-oncogene receptor tyrosine kinase; white coat

Associated
Genotypes

Allelic Composition	Genetic Background
Kit^Mhdasco1/Kit^Mhdasco1	C3HeB/FeJ-Kit^Mhdasco1
Kit^Mhdasco5/Kit^Mhdasco5	C3HeB/FeJ-Kit^Mhdasco5
Kit^Mhdasow3/Kit^Mhdasow3	C3HeB/FeJ-Kit^Mhdasow3
Kit^Whc1/Kit^Whc1	involves: C3HeB/Fe * C57BL/6
Kit^tm1Alf/Kit^Mhdasow3	involves: 129S2/SvPas * C3HeB/FeJ

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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