Phenotype Image Detail

Image

Caption

A: Transmission electron microscopy of the corpus callosum reveals thick abundant myelin sheaths (arrows) present in wild type brain. B: These thick sheaths are completely absent in the brain of the Qki^e5/Qki^e5 mouse, which contain only the occasional thinly myelinated axon (arrow). C: The less severe Qki^qk-v/Qki^qk-v brain is shown for comparison. Magnification x10,500. Coronal sections stained with Lucon Fast Blue staining for myelin lipids shows that the intense blue staining of the corpus callosum in wild type mice is absent in Qki^e5/Qki^e5 and Qki^qk-v/Qki^qk-v mice (inset boxes). Immunohistochemistry using anti-Calbindin antibody reveals cerebellum axonal swellings in the granular cells layer of 3 month old Qki^e5/Qki^e5 mice (E) but not wild type (D). Higher magnification images of the boxed areas in (D) and (E) are shown in (F) and (G) respectively.

This image is from Noveroske JK, Mamm Genome 2005 Sep;16(9):672-82 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:102038

Associated
Alleles

Symbol	Name
Qki^e5	quaking, KH domain containing RNA binding; quaking e5
Qki^qk-v	quaking, KH domain containing RNA binding; quaking viable

Associated
Genotypes

Allelic Composition	Genetic Background
Qki^e5/Qki^e5	B6.101Rl-Qki^e5
Qki^qk-v/Qki^qk-v	B6C3Fe a/a-Qki^qk-v/J

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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