Phenotype Image Detail

Image

Caption

Scanning electron micrographs taken from P1 wild type (+/+, A, B) and Myo7a^Hdb/Myo7a⁺ mice (Hdb/+, C, D). In the apical turn, stereocilia bundles of both inner hair cells (IHC) and outer hair cells (OHC) cover the whole apical hair cell surface and have not formed a polarized staircase array (C) as observed in wild type (A). In the basal turn OHC stereocilia bundles do form a V-shaped staircase but with additional inward pointing wings making them appear more U-shaped (D) and the IHC stereocilia are disorganized (D). Basal IHC stereocilia bundles (D) extend from the whole apical surface of the hair cell compared with the wiild type (B). Scale bar: 10um

This image is from Rhodes CR, Mamm Genome 2004 Sep;15(9):686-97 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:93998

Associated
Alleles

Symbol	Name
Myo7a^Hdb	myosin VIIA; headbanger

Associated
Genotypes

Allelic Composition	Genetic Background
Myo7a^Hdb/Myo7a⁺	C3HeB/FeJ-Myo7a^Hdb/Ieg

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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