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| Caption | Scanning electron micrographs of the organ of Corti of P20 and 3 month old wild type (+/+), Myo7aHdb/Myo7a+ (Hdb/+) and Myo7aHdb/Myo7aHdb (Hdb/Hdb) mice. Outer hair cells (OHC) in the apical coil form O-shaped stereocilia bundles (B, C & H) rather than the normal V-shaped stereocilia bundles seen in the control (A). Inner hair cells (IHC) stereocilia have fused into giant stereocilia (B arrow, D). The IHC fusion is more extensive in the homozygotes with many more IHCs affected (C). By 3 months, ICH stereocilia fusion is evident in almost all IHCs in the apex in heterozygous mutants (F) and signs of stereocilia fusion are seen in the OHCs (F arrow). In homozygotes, very few IHC and OHC stereocilia remain in the apex (G). Scale bar: G, 10um; D & H, 5um. | ||||||
| Copyright | This image is from Rhodes CR, Mamm Genome 2004 Sep;15(9):686-97 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:93998 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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