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| Caption | A-F: Representative images of E18.5 littermate control (A, C, E & G) and Sulf1Gt(OST352220)Lex/Sulf1Gt(OST352220)Lex Sulf2Gt(OST311938)Lex/Sulf2Gt(OST311938)Lex (B, D, F & H) fetuses double stained with alcian blue and alizarin red to demonstrate skeletal elements. A & B: Whole mount images demonstrating the reduced size of the double mutant skeleton. All bones are present, and no obvious fusion defects are apparent in any class of joints. C & D: Skulls viewed from the posterios side. Note the hole in the dorsal side of the basisphenoid bone of the double mutant skeleton (to the right in D). Also note that the palate appears to be developing properly. E-H: Rib cages (skeletal double staining; e, F) and sternum (thresholded CT; G,H) revealing sternebral asymmetry about the midline in double mutant mice (black arrowheads in F, and yellow arrowhead in H). The 4th and 5th sternebrae (counting from rostral to caudal) have a slender site of ossification bridging them at the midline (f, with another example in panel H [yellow arrow]). Scale bars: 1mm | ||||||||||
| Copyright | This image is from Holst CR, PLoS ONE 2007;2(6):e575, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:129305 | ||||||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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