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| Caption | Smarcb1tm1Gvk/Smarcb1+ mice develop head and face tumors. (Left) Tumor present in the soft tissue of the brain penetrating the skull. (Center) Enlarged side of the face because of the presence of tumor mass behind the cheek. (Right) Tumor under the cerebellum has dislodged the eye. B: Immunostain analysis of tumors developed in mutant mice. First row: Paraffin section of normal brain tissue adjacent to tumor HCP01-1103. Second, third and fourth rows represent the immunostain analysis of the paraffin sections of three different mouse tumors (HCP01-1103, HCP02-116 and HCP03-18, respectively) developed in mutant mice. Column 1, hematoxylin and eosin (H & E) staining (a,f,k & p). Colums 2-5 represent immunohistochemical staining using anti INI1 (b,g,l & q), anti-Cyclin D1 (c,h,m & r), anti-smooth muscle actin (SMA) (d,i,n & s); and anti-vimentin (Vim) (e,j,o & t) antibodies, respectively. The arrows point to rhabdoid cells. | ||||
| Copyright | This image is from Tsikitis M, Proc Natl Acad Sci U S A 2005 Aug 23;102(34):12129-34. Copyright 2005 National Academy of Sciences, U.S.A. J:101185 | ||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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