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Phenotype Image Detail
Image
Caption Loss of tyrosine hydroxylase immunoreactivity (TH-IR) in the locus coeruleus (LC), but not substantia nigra pars compacta (SNpc) or striatum of Prkntm1Tmd/Prkntm1Tmd mice. Immunohistochemical staining for TH (C-F: with Nissl counterstain) was performed on coronal brain sections from wild type (A,C & E) and mutant mice (B,D & F) mice. (A & B) Striatum. (C & D) Midbrain with SN and ventral tegmental area. (E & F) LC. (Insets) A lower magnification of the same sections to verify that both pictures represent equivalent planes. Scale bar: 200um
Copyright This image is from Von Coelln R, Proc Natl Acad Sci U S A 2004 Jul 20;101(29):10744-9. Copyright 2004 National Academy of Sciences, U.S.A. J:91487
Associated
Alleles
Symbol Name
Prkntm1Tmd parkin RBR E3 ubiquitin protein ligase; targeted mutation 1, Ted M Dawson
Associated
Genotypes
Allelic Composition Genetic Background
Prkntm1Tmd/Prkntm1Tmd involves: C57BL/6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory