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| Caption | Gross and histological analyses of spermatogenic abnormalities. (a) Reduced testis size in Pafah1b3tm1Cla/Pafah1b3tm1Cla Pafah1b2Gt(Betageo)1Cla/Pafah1b2Gt(Betageo)1Cla and restored testis size in Pafah1b3tm1Cla/Pafah1b3tm1Cla Pafah1b2Gt(Betageo)1Cla/Pafah1b2Gt(Betageo)1Cla Pafah1b1tm1Awb/Pafah1b1+ mice. (b) Testis weights of 8 week old wild type and mutant mice (means +/-SEM, n=10). (c-n) Testicular (x200 in c,e,g,i,k and m) and epididymal (x200 in d,f,h,j,l and n) histology of adult (8 week old) wild type ( c & d), Pafah1b3tm1Cla/Pafah1b3tm1Cla (e & f), Pafah1b2Gt(Betageo)1Cla/Pafah1b2Gt(Betageo)1Cla (g & h), Pafah1b3tm1Cla/Pafah1b3tm1Cla Pafah1b2Gt(Betageo)1Cla/Pafah1b2Gt(Betageo)1Cla (i & j), Pafah1b3tm1Cla/Pafah1b3tm1Cla Pafah1b2Gt(Betageo)1Cla/Pafah1b2Gt(Betageo)1Cla Pafah1b1tm1Awb/Pafah1b1+ (k & l) and Pafah1b1tm1Awb/Pafah1b1+ (m & n) mice. Note that the degenerating germ cells (D), multinucleated giant cells (M), and numerous vacuoles (V) are present in tubules of the testes of mice in g,i, k and m. Some tubules are devoid of germ cells (*), leaving only Sertoli cells in seminiferous epithelium in mice in i. | ||||||||
| Copyright | This image is from Yan W, Proc Natl Acad Sci U S A 2003 Jun 10;100(12):7189-94. Copyright 2003 National Academy of Sciences, U.S.A. J:83818 | ||||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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