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| Caption | (A) Newborn forelimb skeletons (blue, cartilage; red, bone). The humerus in the Shox2tm1Ddu/Shox2tm1.1Ddu Tg(Prrx1-cre)1Cjt forelimb is virtually absent except for a small ossification center (arrow), which is located on the anterior/dorsal surface of the cartilage and does not span the axis of the limb. The rest of the limb is relatively normal, except for a slight broadening of the distal scapula (sc). r, radius; u, ulna; a, autopod. (B) Hindlimbs of newborn mice. The femur (f) in the mutant is represented only by a small cartilaginous extension (arrow) of the pelvic girdle (pg). The tibia (t) and fibula (fi) are also noticeably shorter in the mutant, whereas the autopod (paw) is normal. The ilium (triangle) is also small in the mutant and contains an abnormal asymmetric ossification center similar to that of the humerus in a. (C) Adult forelimb skeletons with bones stained with Alizarin red. The extremely small humerus (h) of the mutant is ossified and fused to the scapula (sc). (D) Adult hindlimbs. The tiny mutant femur (f) is now ossified and fused to the pelvic girdle. The tibia (t) is short and bowed, and the fibula contains an ectopic ossification center (filled triangle). As in newborns, the ilium (triangle) is significantly shorter in the mutant. In contrast, the mutant autopod is of similar size and morphology to that of wild type mice. Scale bar: A & B, 1mm; C & D, 5mm | ||||||||
| Copyright | This image is from Cobb J, Proc Natl Acad Sci U S A 2006 Mar 21;103(12):4511-5. Copyright 2006 National Academy of Sciences, U.S.A. J:107668 | ||||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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