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| Caption | Cohorts of GpnmbR150X/GpnmbR150X Tyrp1b/Tyrp1b mice were aged and analyzed by slit-lamp examination; representative eyes of indicated ages are shown. Each row contains three images of the same eye. The left column shows a broad-beam illumination. The middle column shows transillumination defects. The right column shows the relative dimensions of the anterior chamber. A-C: Until 5 months, double homozygous mutant mouse eyes were indistinguishable from wild type eyes, with a complex iris morphology, not transillumination, and anterior chambers of normal dimension with a closely juxtaposed cornea and iris. D-F: By 6 months, all mutant mouse eyes exhibit a clear phenotype characterized by slight swelling of peripupillary tissue. G-I: In 9 month old eyes, the peripupillary region becomes notably atrophic, transillumination is obvious, and dispersed pigment is present on both the lens and cornea. Beyond this age, a steadily worsening course ensues, which at (J-L) 12 months, (M-O) 14 months, and (P-R) 18 months is characterized by increasing degrees of iris atrophy that include full-thickness iris holes, profound transillumination, pigment dispersion and frequent pigment accumulation on the lens and cornea, and changes to the dimensions of the anterior chamber. | ||||||
| Copyright | This image is from Anderson MG, BMC Biol 2006;4():20, an open-access article, licensee BioMed Central Ltd. J:128215 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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