Phenotype Image Detail

Image

Caption

Mice were aged matched and analyzed by slit-lamp examination; representative Gpnmb^R150X/Gpnmb^R150X Tyrp1^b/Tyrp1^b eyes are shown. A: The normally brown pigmented coat of a mouse on the left compared with a Gpnmb^R150X/Gpnmb^R150X Tyr^c-2J/Tyr^c-2J Tyrp1^b/Tyrp1^b mouse on the right. B,D,F: Different views emphasize the clinical morphology of the albino iris. Eyes of Tyr^c-2J/Tyr^c-2J mice appear pink as they lack melanin, but otherwise the iris and its vasculature have normal morphology. C, E,G: Homozygosity for Tyr^c-2J completely prevents iris disease in triple homozygous mutant mice. The iris morphology of the triple mutant is indistinguishable from that of Tyr^c-2J/Tyr^c-2J only (compare 3B to 3C), lacks peripupillary abnormalities (compare 3D to 3 E), and has a healthy uninterrupted vasculature (3F to 3G).

This image is from Anderson MG, BMC Biol 2006;4():20, an open-access article, licensee BioMed Central Ltd. J:128215

Associated
Alleles

Symbol	Name
Gpnmb^R150X	glycoprotein (transmembrane) nmb; iris pigment dispersion
Tyr^c-2J	tyrosinase; albino 2 Jackson
Tyrp1^b	tyrosinase-related protein 1; brown

Associated
Genotypes

Allelic Composition	Genetic Background
Gpnmb^R150X/Gpnmb^R150X Tyr^c-2J/Tyr^c-2J Tyrp1^b/Tyrp1^b	B6.Cg-Tyrp1^b Gpnmb^R150X Tyr^c-2J

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