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| Caption | Barx2tm1Rsd/Barx2tm1Rsd mouse phenotypes: open eyelids and short whiskers at birth, defective juvenile hair follicle remodeling, and short adult hair. A: Expression of Barx2 mRNA in rump skin at E14.5 detected by in situ hybridization, with expression in epidermis (e) and underlying muscle (m). B: Barx2 expression in epidermis and outer root sheath of hair follicles at P8. C: Two-day-old pups with short whiskers and open eyelids in mutants. D: Follicles in full anagen with no difference between mutant and control. E: Follicles at the anagen-catagen transition with no morphological differences. F: Follicles with catagen morphology for control, but delayed at anagen-catagen transition for mutant. G: Follicles with late catagen morphology for control, but delayed at early catagen for mutant. H: Follicles in telogen for control, but delayed with catagen morphology for mutant. I: Higher magnification of follicles at telogen or early second anagen for control, but sill in catagen with enlarged sebaceous glands (arrows) for mutant. J: Delayed pigment change on the underside of mutant skin indicates an offset in the anterior to posterior remodeling wave. K: All four hair types are shorter in 8 month old mutant mice. | ||||
| Copyright | This image is from Olson LE, Proc Natl Acad Sci U S A 2005 Mar 8;102(10):3708-13. Copyright 2005 National Academy of Sciences, U.S.A. J:96883 | ||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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